Region 1A
#1 Groton Area vs. #8 Waubay/Summit
#4 Sisseton vs. #5 Redfield
#2 Aberdeen Roncalli vs. #7 Tiospa Zina
#3 Milbank vs. #6 Webster Area
Region 2A
#1 Hamlin vs. #8 Clark/Willow Lake
#4 Flandreau vs. #5 Florence/Henry
#2 Estelline/Hendricks vs. #7 Sioux Valley
#3 Elkton-Lake Benton vs. #6 Great Plains Lutheran
Region 3A
#1 Sioux Falls Christian vs. #8 West Central
#4 Baltic vs. #5 Garretson
#2 Dell Rapids vs. #7 McCook Central/Montrose
#3 Madison vs. #6 Tri-Valley
Region 4A
#1 Canton vs. #8 Beresford
#4 Lennox vs. #5 Tea Area
#2 Dakota Valley vs. #7 Parker
#3 Elk Point-Jefferson vs. #6 Vermillion
Region 5A
#1 Platte-Geddes vs. #8 Hanson
#4 Mount Vernon/Plankinton vs. #5 Bon Homme
#2 Wagner vs. #7 Sanborn Central/Woonsocket
#3 Parkston vs. #6 Kimball/White Lake
Region 6A
#1 Miller vs. #8 McLaughlin
#4 Dupree vs. #5 North Central
#2 Mobridge-Pollock vs. #7 Crow Creek
#3 Stanley County vs. #6 Cheyenne-Eagle Butte
Region 1B
#1 Warner vs. #8 Wilmot
#4 Leola/Frederick vs. #5 Aberdeen Christian
#2 Northwestern vs. #7 Britton-Hecla
#3 Hitchcock-Tulare vs. #6 Langford Area
Region 2B
#1 Wolsey-Wessington vs. #8 De Smet
#4 Deubrook Area vs. #5 Arlington
#2 Castlewood vs. #7 Oldham-Ramona-Rutland
#3 James Valley Christian vs. #6 Iroquois/Lake Preston
Region 4B
#1 Alcester-Hudson vs. #8 Irene/Wakonda
#4 Centerville vs. #5 Menno
#2 Gayville-Volin vs. #7 Viborg-Hurley
#3 Freeman vs. #6 Scotland
Region 5B
#1 Burke vs. #8 Colome
#4 Gregory vs. #5 Andes Central/Dakota Christian
#2 Avon vs. #7 Corsica-Stickney
#3 Wessington Springs vs. #6 Tripp-Delmont/Armour
Region 6B
#1 Faulkton Area vs. #9 Sunshine Bible Academy
#4 Lyman vs. #5 Highmore-Harrold
Region 7B
#1 Phillip vs. #8 Crazy Horse
#4 White River vs. #5 Edgemont
#2 Kadoka Area vs. #7 Jones County
#3 Wall vs. #6 New Underwood
Region 8B
#1 Faith vs. #8 Bison
#4 Newell vs. #5 Timber Lake
#2 Harding County vs. #7 Wakpala
#3 Lemmon vs. #6 McIntosh
